Other non-amyloid neuropathological changes, such as Aβ-independent tauopathy, hippocampal sclerosis with TDP-43, α-synucleinopathy, or argyrophilic grain disease, might contribute to and coexist with each other (Wirth et al., 2013; Mormino et al., 2016; Villeneuve, 2016). The gene discussed is TARDBP; the disease is tauopathy.