Lacbay et al. (2018) reported the synthesis of a new category of thienopyrimidine-based bisphosphonate (ThP-BP) inhibitors 52–58 of the human geranylgeranyl pyrophosphate synthase (hGGPPS) that block protein prenylation in multiple myeloma (MM) cells leading to cellular apoptosis. This evidence concerns the gene GGPS1 and AL amyloidosis.