CDKN2A and pancreatic neoplasm: Screening first-degree relatives of individuals with multiple family members affected by pancreatic cancer can help identify disease precursors, as there are numerous syndromes associated with pancreatic cancer, including Peutz–Jeghers syndrome, p16, BRCA and hereditary non-polyposis colorectal cancer (HNPCC) [41, 57, 87].