Numerous systemic conditions and genetic mutations have also been shown to increase the risk of pancreatic cancer, including Peutz-Jeghers syndrome (LKB1/STK11), Li-Fraumeni syndrome (TP53), familial atypical mole-multiple melanoma (FAMMM) syndrome (CDKN2A), Fanconi anemia, and mutations in BRCA1/2, CFTR, KRAS, SMAD4, and FOXC2 [6, 8, 25–27]. Here, SMAD4 is linked to pancreatic neoplasm.