Screening first-degree relatives of individuals with multiple family members affected by pancreatic cancer can help identify disease precursors, as there are numerous syndromes associated with pancreatic cancer, including Peutz–Jeghers syndrome, p16, BRCA and hereditary non-polyposis colorectal cancer (HNPCC) [41, 57, 87]. This evidence concerns the gene CDKN2A and hereditary nonpolyposis colon cancer.