With the approval of new second- and third-generation ALK inhibitors (alectinib, brigatinib and lorlatinib, among others), the therapeutic options for first and subsequent lines of treatment were expanded, offering clinicians a wider repertoire of therapeutic agents for initial treatment and the possibility of choosing between different treatment sequences for advanced ALK+ NSCLC [22, 36–38]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.