First, according to NHANES 2001−2004 data, about 9% of the pediatric population was vitamin D deficient and 61% in the insufficient range; preoperative cholecalciferol or ergocalciferol have not been shown to reduce hypocalcemia rates in pediatric thyroidectomy patients.16,17 Interestingly, in the article by Tsai et al looking to assess intraoperative PTH and hypocalcemia, they screened their pediatric patients for vitamin D deficiency and treated with D3 replacement or provided 50,000 IU D3 to those with unknown levels. The gene discussed is PTH; the disease is vitamin D deficiency.