(a) AOR, adjusted odds ratio; (b) CI, confidence interval; (c) p-value, probability value; †, close to but not statistically significant; (d) PD, progressive disease; (e) ECOG, Eastern Cooperative Oncology Group – Performance Status; (f) 18M S-D: survival at 18-months after cancer diagnosis; (g) 18M S-I: survival at 18-months after starting immunotherapy; (h) CR, complete remission; (i) COPD, chronic obstructive pulmonary disease; (k) NSCLC, non-small cell lung cancer; (m) PD-L1, programmed death-ligand 1. The gene discussed is CD274; the disease is chronic obstructive pulmonary disease.