However, results from Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohorts and Uniform Data Set of the Alzheimer’s Disease (UDS) Centers and Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), both demonstrated significant correlations between APOE ε4 and aging (Heffernan et al., 2016). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.