To the best of our knowledge, this is also the first study to reveal the associations of APOE ε4 and SCD-Q9 scores in subjective and OCI diagnosed based on the combination of SCD-I (Jessen et al., 2014) and the Jak/Bondi standards (Edmonds et al., 2015). The gene discussed is APOE; the disease is Schnyder corneal dystrophy.