The results of the binary logistic regression analysis for NC and OCI indicate carrier status of APOE ε4 and total SCD-Q9 score were independent risk factors of OCI [OR: 2.050, 95% CI (confidential interval): 1.161–3.620, p = 0.013, and OR: 1.444, 95% CI: 1.285–1.622, p < 0.001, respectively]. This evidence concerns the gene APOE and Schnyder corneal dystrophy.