Such blunting effects might further contribute to at least some of the skeletal and tooth manifestations seen in patients with Eiken syndrome.(17, 18) Interestingly, Eiken syndrome is also characterized by a marked delay in ossification, which was speculated, based on mouse studies,(40) to be secondary to selective impairment in the PLC/protein kinase C (PKC)/iCa++ signaling pathway.(1) Delayed ossification was not reported for the patients with the V204E mutation, and our intracellular calcium signaling data did not reveal a defect in signaling through this pathway. The gene discussed is HSPG2; the disease is Eiken syndrome.