P4HA1 and myopia: These findings could explain why P4HA1‐associated disorders are so rare, whereas P4HA2‐associated disorders present with a mild phenotype, mainly high myopia.(32) Nevertheless, the P4ha1+/−; P4ha2−/− mouse model may be useful in screening for potential treatment options, such as bisphosphonates and newer anabolic drugs,(62) in disease caused by pathogenic variants of the P4HA1 gene.