GFAP and Alzheimer disease: Therefore, this research aimed to determine whether purple sweet potato extract has a neuroprotective effect on brain damage caused by oxidative stress, inflammatory processes, and neuronal apoptosis in AD associated with tumor necrosis factor-α (TNF-α) levels, p53 expression, glial fibrillary acidic protein (GFAP) expression, BDNF levels, and spatial working memory.