CD274 and central nervous system cancer: We first did an in silico analysis in CGGA database (mRNAseq_693) where we observed significant positive correlations between FAT1 expression and expression of PD-L1, PD-L2, and IL-10 genes in both primary gliomas (PD-L1: r = 0.229, p < 0.01; PD-L2: r = 0.187, p < 0.01; IL-10: r = 0.196, p < 0.01) and recurrent gliomas (PD-L1: r = 0.253, p < 0.01; PD-L2: r = 0.2, p < 0.01; IL-10: r = 0.135, p < 0.05) (Figures 6A–C).