TGFB2 and neoplasm: Since we found that FAT1 knockdown in tumor cells leads to reduced expression and secretion of TGF-β1/TGF-β2 immunosuppressive cytokines, we next checked if this results in altered migration of monocytes in response to conditioned media from siFAT1-transfected tumor cells as compared to media from siControl-transfected tumor cells.