To further investigate the possible molecular mechanism connecting FAT1 with regulation of TGF-β, we checked siFAT1-treated cells for changes in the level of miR-663a, which has previously been reported to posttranscriptionally regulate TGF-β1 in glioma and hepatocellular carcinoma cells (40, 41, 43). Here, FAT1 is linked to central nervous system cancer.