FAT1 and central nervous system cancer: FAT1 was found to promote the expression of pro-inflammatory mediators such as interleukin (IL)-6, cyclooxygenase (COX)-2, IL-1β, and vascular endothelial growth factor (VEGF)-C in a homogeneous microenvironment of glioma cells where they are likely to sustain glioma growth by serving as autocrine prosurvival cytokines (11, 15–17).