TGFB1 and hepatocellular carcinoma: To further investigate the possible molecular mechanism connecting FAT1 with regulation of TGF-β, we checked siFAT1-treated cells for changes in the level of miR-663a, which has previously been reported to posttranscriptionally regulate TGF-β1 in glioma and hepatocellular carcinoma cells (40, 41, 43).