IGHE and food allergy: In sensitized individuals, crosslinking of these IgE-FcεRI-complexes after re-exposure to the same allergen rapidly leads to release of pro-inflammatory mediators like histamine, tryptase, prostaglandins, leukotrienes, and cytokines, which cause the first early phase response with typical allergic symptoms such as rhinorrhea, airway mucus secretion, broncho-constriction as well as urticaria, vomiting, and diarrhea in the case of food allergies and even leading to anaphylaxis.