IGHE and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: Mutations or deletion of this gene cause severe autoimmune disease known as scurfy phenotype in mice and IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome in humans which suffer from diabetes mellitus, high serum IgE levels, eosinophilia, and food allergy (8–10).