IL6 and AIDS: We have recently shown in a Markov model study that to detect differences on clinical outcomes between 2DR and 3DR based on the effects of IL-6 and D-dimers on severe non-AIDS events previously reported (27) and the IL-6 and D-dimer changes appreciated in TANGO (30) and our study (9), a larger sample size or a longer follow-up will be needed (32).