We have also shown that in DC patients with sepsis, MDSCs significantly enhanced the expression of FOXP3 on CD4+ T cells and behaved as Tregs, while stimulation with l-NMMA (iNOS inhibitor) and nor-NOHA (inhibitor of Arginase1) significantly suppresses the expansion of Tregs in sepsis patients. The gene discussed is NOS2; the disease is Sepsis.