Most subtypes of gasdermin play a pro-inflammatory role in the autoimmune and autoinflammation diseases, including IBD, RA, SSc, EAE, psoriasis, etc. Among the whole types of gasdermin, GSDMD is the most studied subtype of gasdermins due to its tight correlation with inflammasomes activation and the related inflammatory cytokines release. Here, GSDMA is linked to systemic sclerosis.