Interestingly, previous investigation of BRNPs on immune subsets are similar to our observation in that BRNP treatment consistently reduced the infiltration of GR1+ CD11b+ neutrophils to liver during ischemia-reperfusion injury, and lung in a murine bleomycin-induced pulmonary fibrosis model (10, 14). The gene discussed is ITGAM; the disease is pulmonary fibrosis.