IFNA1 and systemic lupus erythematosus: Munroe et al. further found increased levels of circulating IFN-γ in pre-clinical SLE patients prior to detectable upregulation of IFN-α and autoantibody positivity, as well as dysregulation of the chemokines IP-10 (CXCL10) and MCP-3 (CCL7) (92).