Additional genes that influence the IFN pathway and innate immune signaling include IRAK1, which is found on the X chromosome and therefore is thought to contribute increased SLE risk among females (49), and osteopontin, which is also associated with early disease onset (50), as well as IRF7, IFIH1, and TYK2. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.