TRIM21 and systemic lupus erythematosus: Anti-Ro52/Tripartite motif containing-21 (TRIM21) autoantibodies were predictive of SARD progression over the next two years (defined by the 1997 ACR criteria for SLE (103), 2013 ACR-EULAR criteria for systemic sclerosis (104) or 2016 ACR–EULAR criteria for Sjögren’s syndrome (105)), with positive predictive value of 46% and negative predictive value of 89%.