Indeed, we found that B cell KO mice generated significantly milder responses to anti-PD-L1 antibody, TLR-7/8 agonist, or the combination of TLR-7/8 agonist plus anti-PD-L1 antibody than WT mice, as demonstrated by shorter survival (Figure 2A) and larger tumor size (Figure 2B) of the B cell KO mice. The gene discussed is TLR7; the disease is neoplasm.