Severe COVID-19 patients were shown to have higher expression of the alarmin nuclear protein High mobility group box 1 (HMGB1), antiviral molecules like ISG-15 and LL-37, or functionally active tissue factor (TF) as protein cargo in NETs, produced mostly by normal density granulocytes (NDG) (43, 44). The gene discussed is HMGB1; the disease is COVID-19.