Indeed, if autoreactive CD4+ T cells are no longer activated, they in turn cannot signal and activate autoreactive B cells, thus restricting their proliferation and differentiation, leading to a significant reduction in autoantibodies, especially antibodies to native DNA and an improvement in the clinical signs of the disease [as demonstrated in both mice and lupus patients (17, 19, 40)]. This evidence concerns the gene CD4 and systemic lupus erythematosus.