Although the pathogenesis of ICANS is less clear than that of CRS in CAR-T cell therapy studies, high levels of C-reactive protein, IL-6, IL-15, IFN-γ, TNF-α, granzyme B, granulocyte macrophage colony-stimulating factor, IL-2, and IL-8 are associated with severe ICANS (95, 97, 98). Here, CXCL8 is linked to congenital rubella syndrome.