To conclude, this study elucidates the neuroprotective effect of APN in reducing proinflammatory cytokine release and in enhancing hematoma resolution via promotion of M2 microglial polarization and accumulation of M2 microglia in the periventricular area, thereby alleviating neurological deficits in an experimental rat model of GMH (Figure 9). Here, ANPEP is linked to hematoma.