T cells can be loaded with specific osteosarcoma-associated antigens by gene engineering, among which αβT cell receptor-modified T cells, chimeric antigen receptor T cells (CAR-T cells), especially HER-2 CAR-T cells, disialoganglioside GD2 CAR-T cells, and B7H3 CAR-T cells have been discussed the most (89). Here, CD276 is linked to osteosarcoma.