ADAM17 and pancreatic adenocarcinoma: We found that the ADAM17 gene was expressed in nearly all tumor tissues, and was significantly upregulated in five types of tumors, including cholangio carcinoma (CHOL), brain lower-grade glioma (LGG), glioblastoma multiforme (GBM), pancreatic adenocarcinoma (PAAD), and stomach adenocarcinoma (STAD) (Figure 4F), and these tumor tissues expressing ADAM17 at higher levels than corresponding normal tissues in the brain and digestive tract (Figure 4E).