NLRP3 and urticaria: NLRP3 was discovered through its association with autosomal dominant autoinflammatory diseases (NLRP3-AID), also known as CAPS (cryopyrin-associated periodic syndromes), which comprise a spectrum of inflammatory symptoms (e.g. urticaria, conjunctivitis, myalgia, arthralgia, fever, headache, fatigue) of various severity (4).