The collected clinical data supported by serologic evidence of inflammation allowed us to diagnose that the patients suffered from an NLRP3-AID – although the presented features are insufficient to diagnose any particular NLRP3-AID condition such as Muckle–Wells syndrome (MWS), neonatal-onset multisystem inflammatory disease (NOMID), or familial cold autoinflammatory syndrome (FCAS) (5). This evidence concerns the gene NLRP3 and familial cold autoinflammatory syndrome.