NLRP3 and arthritic joint disease: In one Chinese family with an NLRP3 mutation (NM_001127462.1:c.937G>A, NP_001120934.1:p.Glu313Lys) previously linked to MWS, the proband and two other family members had isolated HL, but the other six HL individuals had minor MWS-related inflammatory symptoms such as conjunctivitis and uveitis, oral ulcers, arthralgia and arthritis, and erythematous rash, occurring in different combinations (13).