Meanwhile, the GSVA data reinforced that FBXO5 expression was positively correlated with mitotic spindle, G2/M checkpoint, mTORC1 signaling, PI3K/Akt signaling, and protein secretion in the above six malignancies, as well as inflammatory response of cell immune factors in BLCA, BRCA, and LIHC such as interferon-alpha, interferon-gamma, IL6, and TGF-beta, but in general it was inversely associated with K-ras signaling DN, myogenesis, bile acid metabolism, xenobiotic metabolism, and p53 pathway (Supplementary Figures 8A–F). The gene discussed is IL6; the disease is bladder transitional cell carcinoma.