Second, there are only a few molecular studies on FBXO5 in cancers, including ovarian clear cell carcinoma (9), esophageal squamous cell carcinoma (10), breast carcinoma (11), and hepatocellular carcinoma (12), and thus the findings on FBXO5 in this research need to be further validated in other tumor types. Here, FBXO5 is linked to breast carcinoma.