Recently, several bioinformatics researches proved that FBXO5 could specifically regulate multiple tumor behaviors and exhibited a crucial role in the tumorigenesis and prognosis of several cancers, including squamous cell lung carcinoma (23), breast cancer (24), hepatocellular carcinoma (25), and HPV-positive cervical cancer (26). This evidence concerns the gene FBXO5 and hepatocellular carcinoma.