Among these 25 cancer types, FBXO5 expression all showed Pearson’s negative correlations with gene promoter methylation levels, and the former eight malignancies with the greatest inverse association were respectively presented in Figure 5A, including STAD, CHOL, DLBC, ACC, LIHC, LUAD, UVM, and ESCA (p-value < 0.001 except CHOL, DLBC, and UVM in which p-value < 0.01). This evidence concerns the gene FBXO5 and cancer.