Second, there are only a few molecular studies on FBXO5 in cancers, including ovarian clear cell carcinoma (9), esophageal squamous cell carcinoma (10), breast carcinoma (11), and hepatocellular carcinoma (12), and thus the findings on FBXO5 in this research need to be further validated in other tumor types. The gene discussed is FBXO5; the disease is esophageal squamous cell carcinoma.