This was also true across the individual component responses, where clinically unaffected relatives were less likely to note individual symptoms than their SLE and ILE counterparts (p<0.05) in both LAUREL (baseline and follow-up) and LFRR cohorts (Table 6), yet more likely than matched, unaffected HC to report symptoms, particularly sun sensitivity (p≤0.0098), pleurisy (p≤0.0001), and positive ANA (p≤0.0431). Here, BTG3 is linked to systemic lupus erythematosus.