Lupus relatives meeting clinical criteria at baseline in the LAUREL cohort had similar ANA titers and number of SLE-associated autoantibody specificities as those meeting only serologic criteria, yet higher (p<0.0001) than matched relatives with no ACR criteria and unrelated HC, which had similar profiles (Figure 3A, 4th-5th columns). The gene discussed is BTG3; the disease is systemic lupus erythematosus.