BTG3 and systemic lupus erythematosus: Also of note, relatives who remained clinically unaffected, or met only serologic criteria at baseline, had higher baseline ACR scores than matched HC, likely due to the higher rate of ANA positivity (IIF titer ≥1:120) in clinically unaffected relatives (51%) vs. HC (18%), both of which were significantly lower than those who developed ILE (88%) or transitioned to SLE (91%) (p<0.0001, Table 3).