IL10 and systemic lupus erythematosus: These findings suggest a unique opportunity for intervention in lupus relatives reporting type 2 symptoms with elevated BLyS and/or decreased IL-10 levels, as belimumab has been shown to improve fatigue and quality of life measures in SLE patients (79, 80), while non-pharmacologic modalities such as physical (81, 82) and mindfulness (83) exercises have been shown to increase anti-inflammatory IL-10 levels and decrease fatigue and other type 2 symptoms.