IFNG and systemic lupus erythematosus: In addition to type I IFN, multiple genes that contribute to activation of type II IFN (IFN-γ) pathways are associated with SLE (16, 17), with IFN-γ being among the earliest dysregulated mediators noted in pre-clinical SLE (1, 2), promoting a chronic pro-inflammatory cascade contributing to SLE disease pathogenesis (18, 19).