BTG3 and systemic lupus erythematosus: However, relatives with classified SLE in the confirmatory LFRR cohort had the highest ANA titers and number of SLE-associated autoantibody specificities, followed by relatives who developed ILE, clinically unaffected relatives, and matched HC, with significant differentiation between the groups (p<0.01, Figure 3D, 4th-5th columns).