RNPC3 and systemic lupus erythematosus: This was associated with an increased likelihood of LFRR SLE patients to be positive for autoantibody specificities to dsDNA (44%, p<0.0001), chromatin (49%, p≤0.0002), and nucleosome antigens, including Sm (35%, p<0.0001), SmRNP (43%, p≤0.0001), and RNP (41%, p≤0.0003) compared to relatives with ILE (1-21%), clinically unaffected relatives (1-9%), and unaffected HC (0-3%, Table 8).