In contrast, the regulatory mediator IL-10, observed to be decreased in lupus relatives with type 2 symptoms, along with active TGF-β, previously shown to be a negative predictor of SLE transition in a more limited subset of lupus relatives in the LAUREL cohort (41), were both increased in lupus relatives without clinical ACR criteria at baseline (LAUREL), as well as clinically unaffected relatives and relatives who only developed ILE, but did not have classified SLE at follow-up (LAUREL and LFRR). This evidence concerns the gene IL10 and systemic lupus erythematosus.