Although clinically unaffected relatives had similar ANA titers and number of SLE-associated autoantibody specificities detected (Figure 3), they were more likely than unaffected HC to be positive for autoantibody specificities toward chromatin (10% Rel vs. 0 HC, p=0.0017) at baseline (LAUREL), Ro/SSA (11% Rel vs. 3% HC, p=0.0393) at follow-up (LAUREL), and Ro/SSA (9% Rel vs. 2% HC, p=0.0319) in the LFRR cohort (Table 8). This evidence concerns the gene BTG3 and systemic lupus erythematosus.