SCF, IFN-γ, IL-10, and BLyS, alongside reported type 2 symptoms chronic fatigue, depression, and sleep disturbances, probable SLE (SLE-CSQ score ≥4) based on the SLE-CSQ questionnaire, as well as ACR criteria arthritis, photosensitivity, immunologic criteria, and ANA positivity differentiated unaffected Rel vs. relatives who would transition to SLE prior to disease classification. Here, IFNG is linked to major depressive disorder.