Furthermore, a reduction in ferroptosis accompanied by a decrease in acyl coenzyme A synthetase long chain 4 (ACSL4) and increases in Gpx4, ferritin heavy chain 1 and SLC7A11 was observed in the synoviums and synovial fibroblasts from RA patients compared to those from healthy controls (81). This evidence concerns the gene GPX4 and rheumatoid arthritis.