GPX4 and experimental autoimmune encephalomyelitis: Furthermore, in addition to that in SLE, RA and IBD, ferroptosis also play roles in the pathogenesis of multiple sclerosis, an autoimmune neurological disorder, with mechanisms involving the reduced expression of Gpx4 mRNA in the gray matter of multiple sclerosis patients and decreased Gpx4 protein levels in experimental autoimmune encephalomyelitis mice (19).