The secretion of IFN-γ by NK cells was found to be a positive prognostic marker in chronic myeloid leukemia (CML) (35), while reduced NK cell activity was observed in multiple malignancies, including advanced MM (42), and was associated with high-risk myelodysplastic syndrome (MDS) (43). Here, IFNG is linked to chronic myelogenous leukemia, BCR-ABL1 positive.