Augmenting CAR-NK cells targeting the glioma antigen epidermal growth factor variant III (EGFRvIII) with CXCR4 expression conferred enhanced chemotaxis to U87-MG glioblastoma cells that secrete CXCL12/SDF-1α, a CXC chemokine that binds to receptors CXCR4 and CXCR7 (205). Here, CXCR4 is linked to glioma.