hILC2s in HCC do not express KLRG1, but highly express CD69 and core residency signature when compared with that of normal blood and tissue hILC2s; in mice, KLRG1− ILC2s in HCC can induce immunosuppressive neutrophils to accumulate in tumor tissues by releasing CXCL2, thereby promoting HCC progression (77). The gene discussed is KLRG1; the disease is neoplasm.