In murine breast cancer, adoptive transfer of pulmonary ILC2s promotes the infiltration of IL-13Ra1+ MDSCs in lung metastatic nodules through IL-13/IL-13Ra1; recruited MDSCs increase the number of lung metastatic nodules and reduce the survival of tumor-bearing mice by inhibiting CD4+ T cells and CD8+ T cells and inducing Treg (82). This evidence concerns the gene CD8A and neoplasm.