These TAAs can be further divided into tissue differentiation antigens, such as human carcinoembryonic antigen (77) or MART-1, which are also expressed in healthy tissues; tumor germline (testicular cancer) antigens (e.g., NY-ESO-1 or MAGE-3); tumor cell-overexpressed normal proteins (e.g., EGFR, MUC1, Her2/neu); viral proteins (e.g., EBV, HPV); and tumor-specific mutational antigens (e.g., MUM-1, β-catenin or CDK4) (78, 79). The gene discussed is CEACAM5; the disease is neoplasm.