Among them, CXCR3 and its chemokines CXCL10, CXCL9, and CXCL11 are widely involved in the pathogenesis of autoimmune diseases such as HT, GD, thyroid eye disease (TED), type 1 diabetes, and autoimmune Addison’s disease, and may be potential targets for new drugs to treat these diseases (43, 44). This evidence concerns the gene CXCR3 and chronic primary adrenal insufficiency.