SCRG1 and synovitis: Combined with the above difference analysis results and the basic research results of SCRG1 gene in the literature, SCRG1 gene was significantly different in all microarray and RNA-seq data sets, and was upregulated in all analysis data sets, and the role and function of SCRG1 gene in OA synovitis was not clear; therefore, it is very important to study the function and possible mechanism of SCRG1 in OA synovitis.