CD8A and neoplasm: Moreover, incubation of L2-9-mer- and O-10-mer-stimulated CD8+ T cells with CFPAC-1 cells triggered IFN-γ secretion, which was decreased to baseline levels when anti-MHC-I antibodies were present, showing that the recognition of the tumor cells by the CD8+ T cells is HLA-restricted (Figure 4E).