More recently, it has been shown that ILC2s are further characterized by the expression of the killer cell lectin-like receptor subfamily G member 1 (KLRG1), a co-inhibitory receptor previously reported in T and NK cells that binds to the members of the cadherin family and is upregulated during infection in response to IL-25 (20, 47). The gene discussed is KLRG1; the disease is infection.