LAG3 and neoplasm: This cluster is characterized by the expression of cytolytic effector genes, including FGFBP2, FCGR3A, CX3CR1, GZMB, GZMH, and PRF1. Moreover, these cytotoxic ILC1s are mainly enriched in non-tumor tissues, while in tumor samples ILC1s are characterized by higher levels of exhaustion markers, such as LAG3, thus suggesting that ILC1s could undergo functional conversion during liver cancer progression.