Meanwhile, we found that the numbers of CD3+ T cells and the CD4+, CD8+ subsets not only in different patients but also in different tumor regions and corresponding normal tissue of the same patient varied greatly in PTC-W and PTC-WO, such as P1 versus P2/P3, and PH1 versus PH2/PH3 (Figures 1B, C, S1A, B). This evidence concerns the gene CD4 and neoplasm.