Table S1 showed the clinical characteristics of 20 patients with PTC-WO and 20 patients with PTC-W. The clinical characteristics of patient with PTC-WO and PTC-W were comparable, except for preoperative TSH, anti-TPOAb and anti-TGAb. We performed immunohistochemistry analysis of CD3, CD4, and CD8 on all tumor and matched normal samples from 40 patients and TCR high-throughput sequencing on 24 tumor samples and 12 normal samples from 12 patients (Figure 1A and Tables S2, S3). Here, CD4 is linked to neoplasm.