Moreover, C1QTNF3 has been shown to exert beneficial effects on metabolism and inflammation in vivo; administration or transgenic overexpression of C1QTNF3 attenuated diet-induced hepatic steatosis and lowered glucose levels in Ob/Ob mice (26, 27) and C1QTNF3 knockout mice are more susceptible to collagen-induced arthritis in mice (28). The gene discussed is C1QTNF3; the disease is fatty liver disease.