C1QTNF3 and obesity due to melanocortin 4 receptor deficiency: Moreover, neither genetic overexpression nor knockout of C1QTNF3 alters the GWAT and the systemic inflammatory response to a sublethal dose of LPS in vivo, and mice overexpressing C1QTNF3 display increased levels of several chemokines, although this difference between genotype disappears when animals are challenged with HFD/obesity (53).