C1QTNF3 and neoplasm: Previous research suggests that C1QTNF3 exerts anti-inflammatory effects (22, 23, 25, 28), and we were therefore initially surprised to find that antibody-mediated blockage of C1QTNF3 reduced the tumor-induced macrophage accumulation along with the chemotactic and pro-inflammatory effects of C1QTNF3 on bone marrow derived macrophages in vitro.