Patients with type-2 diabetes have lower circulating C1QTNF3 levels (29) and visceral adipose tissue C1qtnf3 levels are reduced in obesity/insulin resistant conditions (30–32), but less is known about C1qtnf3 regulation in subcutaneous adipose tissue. The gene discussed is C1QTNF3; the disease is obesity due to melanocortin 4 receptor deficiency.