To date, there are various FTO inhibitors with anti-leukemia activity in AML, including the natural compounds radicicol, Saikosaponin D, FB23-2, CS1 and CS2 (101, 102, 119, 120).Among them, FB23-2, CS1, and CS2 can reduce the numbers of LSCs. The gene discussed is FTO; the disease is acute myeloid leukemia.