NOPCHAP1 and myeloid sarcoma: It is of particular relevance that we have defined by in-silico analysis three protein-coding genes controlled by both circRNA molecules identified in this study: NOS1, NOPCHAP1, and DSE. NOS1 was repeatedly implicated in oxidative stress in immune cells and tissue in MS, blood–brain barrier permeability, and microglia function (34, 35).