It is of particular relevance that we have defined by in-silico analysis three protein-coding genes controlled by both circRNA molecules identified in this study: NOS1, NOPCHAP1, and DSE. NOS1 was repeatedly implicated in oxidative stress in immune cells and tissue in MS, blood–brain barrier permeability, and microglia function (34, 35). Here, DSE is linked to myeloid sarcoma.