Other TRPs, such as TRPV4, TRPV1, and TRPM3, are critical in alveolar bone remodeling via regulating RANKL/OPG signaling pathway under mechanical stress without periodontitis [42–44], while in periodontitis, little is known about the role of TRPs and the expression and functions of TRPA1 in periodontitis are rarely studied. Here, TRPV1 is linked to periodontitis.