Other TRPs, such as TRPV4, TRPV1, and TRPM3, are critical in alveolar bone remodeling via regulating RANKL/OPG signaling pathway under mechanical stress without periodontitis [42–44], while in periodontitis, little is known about the role of TRPs and the expression and functions of TRPA1 in periodontitis are rarely studied. This evidence concerns the gene TRPV4 and periodontitis.