LPS caused remarkable mtDNA release in healthy HGFs and led to more significant mtDNA release in periodontitis-affected samples (Figures 2(b)–2(d), and 2(e), Movie 2 and 3).Next, we calculated a significant increase in the percentage of HGFs with mtDNA efflux in CP HGFs as compared with that in control HGFs (Figure 2(f)). This evidence concerns the gene CP and periodontitis.