TNF and age-related macular degeneration: To further figure out the function of SIRT1 in AMD, hypoxic cells were transfected with sh-SIRT1, and the results showed that the expression of VEGF, TNF-α, and IL-6 was decreased, cell viability was increased, and the cell migration, apoptosis, and angiogenesis were impaired, indicating that SIRT1 silencing exerted protecting effects on AMD progression.