In summary, our evidence pointed toward that SIRT1 deacetylated SOX9 to promote its nuclear translocation, thereby increasing the expression of LCN2, further inducing the secretion of VEGF and inflammation-related factors, as well as cell apoptosis, migration, and angiogenesis, and ultimately promoting the formation of blood vessels in CNV-induced AMD (Figure 6). The gene discussed is VEGFA; the disease is age-related macular degeneration.