To further figure out the function of SIRT1 in AMD, hypoxic cells were transfected with sh-SIRT1, and the results showed that the expression of VEGF, TNF-α, and IL-6 was decreased, cell viability was increased, and the cell migration, apoptosis, and angiogenesis were impaired, indicating that SIRT1 silencing exerted protecting effects on AMD progression. Here, VEGFA is linked to age-related macular degeneration.