In contrast to nutlin, which blocked the p53/MDM2 complex and induced p53 accumulation in mouse cells, RITA did not disrupt mouse p53/MDM2 interaction and did not induce p53 in mouse tumor cells and mouse embryonic fibroblasts (MEFs) expressing Ras and c-Myc oncogenes (Figures 5E,F). Here, MYC is linked to neoplasm.