During tumor progression, high expression of specific oncoproteins in tumor cells may recruit immunosuppressive lymphocytes, such as MDSCs (Taki et al., 2018), regulatory T cells (Tregs) (Lu et al., 2021), and enhance their immunosuppressive function, or make anergy of tumor-killing lymphocytes such as CD8+ T cells and NK cells (Crespo et al., 2013; Judge et al., 2020), creating an ecological environment suitable for tumor growth. This evidence concerns the gene CD8A and neoplasm.