Previous studies found that CD206 + M2 macrophage cells and Treg cells exert immune suppression function in the TME of HCC (Allavena et al., 2008), our study found that RAB42 may be involved in the recruitment of these immunosuppressive immune cells into the TME, which needs further experimental verification in the future. The gene discussed is RAB42; the disease is hepatocellular carcinoma.