GPX4 and Hepatic fibrosis: Kuo et al. (2020) found that chrysophanol isolated from the rhizome of rhubarb can inhibit hepatitis B virus x protein (HBx)-induced activation of HSCs through ER stress and ferroptosis-dependent and GPX4-independent pathways, thereby reducing liver fibrosis. In addition, wild bitter melon extract can downregulate the protein levels of GPX4 and SLC7A11 in LPS-induced HSCs, suggesting that wild bitter melon extract can exert an anti-hepatic fibrosis effect by inducing ferroptosis (Ho et al., 2021).