SLC7A11 and hepatocellular carcinoma: Another study showed that the key driver of HCC resistance to sorafenib is YAP/TAZ, which not only induces the expression of SLC7A11 in a TEAD-dependent manner but can also maintain the stability, nuclear localization, and transcriptional activity of ATF4 protein, and then synergistically induce the expression of SLC7A11, thereby inhibiting sorafenib-induced ferroptosis (Gao et al., 2021) and increasing resistance to sorafenib.