ECH1 and metabolic dysfunction-associated steatohepatitis: Studies have shown that ECH1 knockdown can aggravate liver steatosis, inflammation, and fibrosis in mice, while ferrostatin-1 intervention can alleviate the pathological changes aggravated by ECH1 knockdown, suggesting that ECH1 may slow the progression of NASH in mice by inhibiting ferroptosis (Liu B. et al., 2021).