HMOX1 and Hepatic fibrosis: Heme oxygenase 1 (HO-1) is the upstream molecule of magnesium isoglycyrrhizinate-induced ferroptosis in HSCs, and siRNA knockdown of HO-1 can block magnesium isoglycyrrhizinate-induced ferroptosis in HSCs, thereby promoting liver fibrosis (Li Y. et al., 2020), suggesting that magnesium isoglycyrrhizinate alleviates CCl4-induced liver fibrosis by promoting HO-1-mediated ferroptosis in HSCs.