The Kaplan–Meier curve analysis demonstrated that high expression of KCNN4 could exert unfavorable influences in the survival indicators (Figures 4A–C), including KIRP (DSS: p = 0.021; PFI: p = 0.029), LGG (OS: p < 0.001; DSS: p < 0.001; PFI: p = 0.002), MESO (OS: p = 0.044; PFI: p = 0.006), PAAD (OS: p = 0.001; DSS: p = 0.008; PFI: p = 0.003), GBM (OS: p = 0.004; DSS: p = 0.003; PFI: p = 0.003), LUSC (PFI: p = 0.023), and KIRC (OS: p < 0.001; DSS: p < 0.001; PFI: p < 0.001). The gene discussed is KCNN4; the disease is glioblastoma.