Synuclein alpha (SNCA) variants associated with PD are of two types: one has missense mutations, such as p.A30G, p.A30P, p.E46K, p.H50Q, p.G51D, p.A53T/E/G/V, and p.E83Q, whereas the other has amplifications, including duplication and triplication (5, 8, 12, 36–43). This evidence concerns the gene SNCA and Parkinson disease.