RENBP and early-onset autosomal dominant Alzheimer disease: As shown in Figure 8 and Table 5, the top 10 of the 20 KEGG pathways in ZGCD were pathways in cancer (degree = 65), proteoglycans in cancer (degree = 65), malaria (degree = 42), adrenergic alarm signaling in cardiomyocytes (degree = 41), AGE-RAGE gating pathway in diabetes-related complications (degree = 36), oxytocin-indicating path (degree = 35), Alzheimer disease (degree = 31), fluid shear stress and atherosclerosis (degree = 28), Epstein–Barr virus infection (degree = 27), and HIF-1 signaling pathway (degree = 20).