In HCC, several ways have been recognized to be implicated in HCC progressions promoted by HCC-associated MSCs (HCC-MSCs), such as long non-coding RNA (lncRNA) dynamin 3 opposite strand/lysine demethylase 6B/T-cell lymphoma invasion and metastasis-inducing protein 1 axis, lncRNA MSC-upregulated factor, and S100 calcium-binding protein A4/microRNA-155/suppressor of cytokine signaling 1/matrix metalloproteinase 9 axis (18–20). The gene discussed is KDM6B; the disease is hepatocellular carcinoma.