Sotgia combined four mitochondrial proteins (uL15m, HSPD1, UQCRB, and COX17) to generate a compact mitochondrial gene signature that successfully predicts distant metastasis in breast cancer, suggesting that mitochondrial biogenesis should be considered a novel therapeutic target to overcome tumor recurrence, distant metastasis, and treatment failure in breast cancer (95). This evidence concerns the gene MRPL15 and breast carcinoma.