SIRT1 and neoplasm: Bioinformatics analyses have revealed that MRPS5 is closely related to the function of OXPHOS complex I and the acetylation status of MRPS5 is directly regulated by the NAD+-dependent deacetylase sirtuin-1 (SIRT1), indicating that the SIRT1/MRPS5 axis is involved in metabolic reprogramming and tumor progression (25).